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Mitochondria produce ROS during adenosine triphosphate (ATP) generation, with some electrons leaking from the electron transport chain (ETC), which subsequently leads to superoxide anion production [66]

[DOI] [Google Scholar] Blanca A.J., Ruiz-Armenta M.V., Zambrano S., Salsoso R., Miguel-Carrasco J.L., Fortuo A., Revilla E., Mate A., Vzquez C.M

There are a few suggested triggers for patients with ME/CFS to develop autoimmune symptoms

Prevalence of age-related macular degeneration in the United States

TMAO is also associated with significantly higher hospitalization rates, renal dysfunction and cardiac death [16]