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However, HS014 does have MC3R antagonist activity and the relatively small difference in affinity for MC4 vs

Cumulative effect of simvastatin, L-arginine, and tetrahydrobiopterin on cerebral blood flow and cognitive function in Alzheimers disease

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doi:10.1146/annurev.arplant.48.1.109

This effect comes from the activation of central mechanisms responsible for sexual arousal