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Furthermore, the CVS CHI group had heightened degree of inflammation, based on Iba1 immunohistological signal in hippocampal regions, with strong degree of correlation between heightened neuroinflammation and neurobehavioral deficits (Fesharaki-Zadeh et al., 2020

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Transcriptome analysis revealed that in different neurodegenerative diseases, including MS, activated microglia share, in part, the same gene signature, and have been named disease-associated microglia (DAM) (137)