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Indeed, treatment of mice bearing autochthonous breast cancers, or cancer allografts, with CDK4/6-inhibitors together with anti-PD-1/PD-L1-antibodies enhanced the efficacy of immune-checkpoint blockade and led to complete tumor regression in high proportion of animals (114, 115, 118)

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PMID: 15347232 Scuderi, G.J, Vaccaro A.R.., Fitzhenry, L.N., Greenberg, S., Eismont, F.: Long-term clinical manifestations of retained bullet fragments within the intervertebral disk space

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When the agouti gene is methylated (as it is in normal mice), the coat color is brown and the mouse has a low disease risk