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Phosphodiesterase-5 (PDE5) inhibitors remain the first-line pharmacological treatment for ED according to NICE guidance

Acetyl-L-carnitine (ALC) is an amino acid that supports energy levels, maintains energy production, supports physical endurance, and aids in post-exercise recovery

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Declaration of patient consent The authors certify that they have obtained all appropriate patient consent forms

doi: 10.1016/j.pcl.2025.01.003 Saneeha Shahid , Peter F Aziz , Iqbal El Assaad , Brendan J Burke , Kenneth Zahka , Tara Karamlou , Justin T Tretter , Maryann Patterson , Akash Patel

Although systematic assessment of carnitine status has been recommended in VPA-treated patients [27, 29], hypocarnitin-aemia has not been confirmed in all studies