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By focusing on the early propagation of the tracer within the subarachnoid space, the same group provided evidence for the existence in human of a space around the major arteries, delineated by a semi-permeable membrane, that facilitates the anterograde transport of solutes inside the brain (39)

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In contrast to the relatively smaller outbreaks of SARS-CoV in 2002 and MERS-CoV in 2012, SARS-CoV-2 is exhibiting an unprecedented scale of infection, resulting in a global pandemic declaration of Coronavirus Infectious Disease (COVID-19) on 11 March 2020 by the World Health Organization (WHO)

Complex manufacturing processes and the need for precise control over particle properties hinder scalability, while immune responses and inefficient BBB targeting present additional obstacles

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Within the first week, the stiffness disappeared