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Abstract Patients affected by chronic kidney disease (CKD) or end-stage renal disease (ESRD) experience a huge cardiovascular risk and cardiovascular events represent the leading causes of death

On the other hand, senomorphic drugs modulate SASP and suppress secretory potential without eliminating senescent cells [76]

In addition, metformin could regulate DNA/histone modifications and miRNAs to carry out transcriptional regulatory processes (

Use cautiously in patients with kidney dysfunction

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Together, these results suggest that the cohesin loader does not discriminate between the two RSC isoforms and stimulates chromatin remodeling by both the RSC1 and RSC2 complexes