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Description
Colorectal high-grade neuroendocrine carcinoma: A single institution experience
doi: 10.1016/j.exger.2004.05.007
However, ACSL4 is not necessary for all ferroptotic cell death, which means under special circumstances ferroptosis is able to be induced in ACSL4-depleted cells ( Ferroptosis is induced due to lipid peroxidation activated via non-enzyme-dependent (Fenton reaction) and enzyme-dependent processes
PMID: 17018654
It also chelates metal ions (like iron and copper) that contribute to radical generation, further mitigating oxidative stress (71)
P., & Lazerson, J
