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Other mechanisms by which these PPAR agonists prevent oxidative stress include a decrease in iNOS activity, NFB blockade, inhibition of TNF- release, or activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) 138

Proc Natl Acad Sci USA (2016) 113:E680612

Additionally, melatonin can regulate neuroinflammation by reducing NF-B activation and enhancing NRF2 expression to reduce oxidative stress (Negi et al

Organisms rely on antioxidant systems to neutralize ROS (Loboda et al., 2016)

Pritchard, J
