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J Am Board Fam Med 2009;22:528-34

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In particular, negative results were reported with endostar, sunitinib, sorafenib, vandetanib, or thalidomide in combination with chemotherapy in the first-line setting, with sunitinib as maintenance therapy, with sunitinib, cediranib, and nintedanib as single agents or ziv-aflibercept in combination with topotecan in second-line setting