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In human Chang liver cells, overexpression of GPx1 was found to decrease ATP production and mitochondrial ROS-mediated functions such as disulfide bond formation and growth factor-mediated signaling [16]

However, in root tip, a marked change in the DAB and NBT staining was observed (Supplemental Figure 2 E-G)

More notably, substantial CD8 + T-cell infiltration and aberrant PD-L1 signaling have been observed in AD brain tissues, suggesting the presence of a locally immunosuppressive microenvironment

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