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20 The detection of polyclonal antibodies in lupus sera in comparison to monoclonal antibodies in the case of B-CLL and clinically silent individuals, indicates that the lower yield is not due to possible differences in affinity binding in polyclonal antibodies

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doi: 10.3109/00365513.2013.773591

10.1111/ajt.14186 56

The principal molecular mechanisms that mediate epigenetic regulation of gene expression are DNA methylation, histone posttranscriptional modifications (methylation, acetylation, phosphorylation, ADP-ribosylation, ubiquitination, and SUMOylation), and the expression of noncoding RNAs (Cheng et al., 2012[88])