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For example, proton pump inhibitors (PPIs) and H2 receptor antagonists, commonly used to treat gastroesophageal reflux disease (GERD), can reduce the absorption of vitamin B12 and may necessitate adjustments in the dosing of methylcobalamin

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As Jadad scoring relates purely to risk of bias, other variables affecting study quality such as presence of placebo arm, population size, power and duration of follow-up are addressed in text