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Whilst ROS can contribute to the onset of fatigue, there is increasing evidence that they play a crucial role in exercise adaptations

In macrophages, especially those recycling senescent red blood cells in the spleen and liver, dysregulation of HO-1 or impaired iron export can contribute to local iron deposition and oxidative stress (3234)

However, the research was conducted solely on the Korean population whose metabolic characteristics related to BMI and T2DM could be different from those of other ethnicities, thus requiring further evaluations (Jeong et al., 2020)

Since distinct permutations of these factors alter constituent yields and material properties, identifying optimal conditions is essential to maximize productivity while minimizing energy consumption

Lee SY, Shi LS, Chu H et al (2013) Rhodiola crenulata and its bioactive components, salidroside and tyrosol, reverse the hypoxia-induced reduction of plasma-membrane-associated Na,K-ATPase expression via inhibition of ROS-AMPK-PKC pathway

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