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Curcumin-piperine supplementation may offer a safe and viable therapeutic option that could slow the progression of nonalcoholic fatty liver disease

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15 , e1002660 (2018)

18 , e040521193121 (2022)

have demonstrated that TGF- enhances the immunosuppressive capabilities of MDSCs in non-small cell lung cancer patients by activating the mTOR/HIF-1 signaling pathway, which in turn upregulates the expression of CD39 and CD73 on MDSCs (114).We postulate that the development of small molecule inhibitors or antibodies specifically targeting HIF-1 activity, or the utilization of existing mTOR inhibitors (such as rapamycin and its derivatives), may effectively impede the activation of HIF-1 by TGF-, thereby inhibiting the recruitment and activation of MDSCs

Usually, damaged melanocytes are eliminated through apoptosis and senescence, but research by Ken et al suggests that MSCs depletion may occur due to ectopic differentiation and impaired renewal