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Due to the involvement of inflammatory cytokines in RA, anti-inflammatory agents have been of interest in treatment of this disorder

187 Recent studies have suggested that zinc plays a crucial role in preserving the integrity of mucosal barriers, which is linked to the immunological responses of gastrointestinal diseases in the mucosa 188,189,190 (Fig

Simultaneously, it downregulates genes associated with inflammation (IL-6, TNF-alpha), oxidative damage, fibrosis (TGF-beta in some contexts), and tissue destruction (certain metalloproteinases)