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The report of the Institute of Medicine (IOM) of the United States in 2011 not only discussed the upper limits (ULs) of the intake of high-dose vitamin D preparations during acute and short-term administration within a limited time period, but also emphasized the long-term administration of vitamin D

Along with VDAC1, TSPO is a regulator of mitophagy, and when there is an imbalance in the expression of these OMM proteins, ROS accumulate and lead to mitochondrial dysfunction [26]

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