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BMC Genomics 15 (257), 257

Microbiota-derived butyrate regulates intestinal inflammation: focus on inflammatory bowel disease

This improvement was hypothesized to be attributed to its purported anti-inflammatory action, including a potential decrease in myeloperoxidase (MPO) activity and histological inflammatory cell influx

Updates from ICARIA-MM, a phase 3 study of isatuximab (Isa) plus pomalidomide and low-dose dexamethasone (Pd) versus Pd in relapsed and refractory multiple myeloma (RRMM)

Vitamin D/vitamin D receptor (VDR) signaling intersects inflammation, oxidative stress/mitochondrial injury, fibrogenic pathways, the reninangiotensinaldosterone system (RAAS), and the gutkidney axis, providing a biologic rationale for renoprotection

Other negative modulators of NRF2 are: CR6-interacting Factor 1 (CRIF1), a protein previously known as a cell cycle regulator and transcription cofactor, which is able to negatively regulate NRF2 protein stability under both reducing and OS conditions through physical interaction with both N- and C-terminal regions of NRF2 [229]