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As summarized in Table 1, these strategies can be broadly categorized into endogenous stimulation (e.g., pH, enzymes, ROS) and exogenous/multimodal stimulation (e.g., light, ultrasound, magnetic field)

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While such optimizations to trial design may succeed in gaining approval for additional immunosuppressive therapies, allowing pharmaceutical companies to claim their share of the insurance market, they do nothing to genuinely benefit patients with UC and instead contribute to escalating healthcare costs

Transsulfuration Pathway Alternatively, methionine can be metabolized via the transsulfuration pathway, leading to the synthesis of cysteine, another important amino acid