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The driver may be systemic or involve a different pathway, including mast-cell activation

Chang, R., Mamun, A., Dominic, A

Reality: Different pills operate differently, and the effectiveness varies greatly depending on the substances utilized

Where in upregulated miR-29b directly targets collagen genes (COL1A1/COL3A1/ELN) to attenuate post-infarction fibrosis (Melo et al., 2014), while exercise-induced HIF-1 activates miR-126, promoting angiogenesis via PI3K/AKT/eNOS and MAPK pathways in infarcted hearts (Song et al., 2020)

Concussion is often referred to as the mildest end of the mild TBI spectrum

Yuan H, Ma Q, Ye L, Piao G