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Knockdown of NLRP3 or caspase-1 reduced neuronal death and reversed cognitive impairments [147], whereas PARP-1 -/- mice were observed to prevent synaptic damage, cognitive dysfunction, and microglial activation in an AD mouse model referring to the significant role of pyroptosis and parthanathos in the pathogenesis of AD [148, 149]

GIP receptor activation at low doses supports mitochondrial function in adipose tissue and may contribute to improved fatty acid metabolism independent of the dramatic appetite suppression seen at full doses

58 JokovicN.NikolicM.BegovicJ.JovcicB.SavicD.TopisirovicL

The highest fold change in the gene level - approximately 44 times higher in IL-8 expression, was observed in 580 M CuCl 2 treated cells when compared to control

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The transplantation of ECFCs into the vitreous humor appeared to result in their incorporation into the damaged retinal vasculature