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(2010) Proceedings of the National Academy of Sciences (PNAS) , 107(5): 19181923 Key mechanistic study confirming that PNC-27 adopts an HDM-2-binding conformation superimposable with p53 residues bound to HDM-2

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Approximately 12 hours after his last dose of kratom (15 capsules, ~11 g), he had a Subjective Opiate Withdrawal Scale (SOWS) of 20 and began the induction with oral buprenorphine/naloxone (8 mg/2 mg) (Fig

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