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Increased generation of reactive oxygen species, decreased activity of antioxidant systems or both mechanisms may be involved in the occurrence of oxidative stress ( A study showed that lenalidomide attenuates oxidative cardiovascular tissue damage and apoptosis in obese mice by inhibiting tumor necrosis factor (Zhu et al., 2014)

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Gene 637 , 196202 (2017)

[DOI] [PMC free article] [PubMed] [Google Scholar] [72].Derry S, Gill D, Phillips T, Moore RA, Milnacipran for neuropathic pain and fibromyalgia in adults, Cochrane Database Syst

the liver being the most prominent place of accumulation, as we have already seen)