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The mechanism(s) of action underlying these changes is currently unclear, but results of preclinical work supports effects of ARA 290 on insulin resistance and muscle mitochondrial biogenesis (10) as well directly on insulin release (38)

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doi:10.1021/bi900558g Wall SB, Smith MR, Ricart K, Zhou F, Vayalil PK, Oh JY, Landar A (2014) Detection of electrophile-sensitive proteins