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In physiological conditions the plasma concentration of PC is 70 nM, while the concentration of its activated form, APC, is estimated as low as 40 pM 2

For eye drop administration, animals were gently restrained without the need for anesthesia

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Verdich C, Flint A, Gutzwiller JP, Naslund E, Beglinger C, Hellstrom PM, et al

Lastly, the presence of L-histidine did not significantly affect the expression of aatJ - lacZ in any of the three investigated strains