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However, a recent paper showed that dexamethasone administration increased the basal expression of GCLC and GSH levels in the spiral ganglion of the mouse cochlea (Nagashima and Ogita, 2006)

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The polar and charged residues lining the enzymes binding pocket likely contribute to the formation of an electrostatic environment essential for substrate interaction ( 115 inactivates CHAC1, preventing GSH depletion in vivo ( The molecular mechanism of -glutamyl amino acid degradation by GCT family enzymes is well understood

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