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Supplementary material The Supplementary Material for this article can be found online at: Abbreviations CKD, chronic kidney disease

We propose that the activation of AMPK is the main mechanism for EGCG and other catechins to influence energy metabolism and to alleviate MetS, and this proposal will be referred to as the AMPK hypothesis. AMPK is activated by phosphorylation of Thr172 in the activation loop within the kinase domain of the -subunit

[DOI] [PubMed] [Google Scholar] 9.Tanphaichitr V., Leelahagul P

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that is, the increase in energy expenditure was observed in short-term (710 days) studies with catechins, but not in long term studies [42]