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Figure 4c), suggesting that CoQ 10 could also be protective in the ONH astrocytes by triggering mitochondrial biogenesis against oxidative stress

To this extent, melatonin receptors recruit further downstream messengers, cascades and transcription factors, thereby involving other pathways such as PI3K/PKC/cRaf/MEK/ERK (Chen et al., 2020a), PKC (Soto-Vega et al., 2004), Ca 2+ /CaMKs (Fukunaga et al., 2002

J., & Cheng, T

doi: 10.4149/gpb_2014041

Where if a person consumes an adequate amount of vitamin B12 in their diet, their body may not be able to absorb it effectively, which can lead to deficiency