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The biggest talking point is how these two peptides create a 1 + 1 = 3 effect
Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS
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[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Goodridge HS, Wolf AJ, and Underhill DM 2009

They are engaged by specific ligands on target cells

The change is not just physical
