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CK1 and GSK3 sequentially phosphorylate the amino terminal region of -catenin, resulting in -catenin recognition by -Trcp, an E3 ubiquitin ligase subunit, and subsequent -catenin ubiquitination and proteasomal degradation (He et al., 2004)

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This is especially important for glutathione because your natural production of this molecule begins to decline as early as your 20s

J Chrom A 893:207213 Liu L, Howe P, Zhou YF, Hocart C, Zhang R (2002) Fatty acid profiles of leaves of nine edible wild plants: an Australian study