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Nrf2 -null mice suffer from acute hepatotoxicity after acetaminophen exposure ( Nrf2 -null mice ( Nrf2 -null mice are more susceptible to cigarette smoke-induced emphysema (Rangasamy et al., 2004), bleomycin-induced pulmonary fibrosis ( Nrf2 gene has been linked to the reduced expression of Nrf2 and subsequent lung damage caused by hyperoxia ( NRF2 gene also harbors SNPs in the promoter region (Yamamoto et al., 2004), which have been linked to the risk of acute lung injury (Marzec et al., 2007)

Our recent study identifying WASF3 as a potential mediator of mitochondrial dysfunction highlights the involvement of cellular energy production, ER stress and immunity in ME/CFS (115)

Tandem mass spectrometry (MS/MS) Reliable identification and quantification of mycotoxins and their metabolites demand high levels of selectivity of the mass spectrometric methods