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In a model of methotrexate-induced kidney injury, the administration of UMB reduced the expression of inflammation mediators P 38 MAPK and NF-B and the pro-apoptotic molecules BAS and caspase3 while increasing anti-apoptotic levels of the BLC-2 molecule [86]

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Model performance was validated using a 10-fold cross-validation with 50 iterations

Lokhorst HM, Plesner T, Laubach JP, Nahi H, Gimsing P, Hansson M, et al

Nrf2 KO mice and Trsp KO mice are not anemic

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