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Well, if you're taking antioxidants, you do care about pro-oxidants

Multiple investigations have demonstrated a negative correlation between the activity of GPX3 and the development of carotid atherosclerotic plaques, suggesting that diminished GPX3 activity could serve as an autonomous prognostic indicator for carotid atherosclerosis in individuals with type 2 diabetes mellitus (T2DM) [145,146]
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Its very energetically demanding

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