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10.1523/JNEUROSCI.0426-16.2016 10 AlamZ

Antioxidant systems such as superoxide dismutase, glutathione (GSH), glutaredoxin, heme oxygenase and thioredoxin (TRX) systems protect cells from the pathological effects of ROS

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As the effective dose is near to LD 50 , therefore it has shown to cause neurotoxic effects

More broadly, dietary polyphenols like gallic and ferulic acid are recognized for reversing aberrant epigenetic marksthey can inhibit DNA methyltransferases or HDACs, reactivating silenced tumor suppressor genes (153)

The resulting solution was then centrifuged and the supernatant containing collagen was collected and diluted to 2 mg/mL with 17.4 mM acetic acid