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Additionally, navitoclax is almost impenetrable to the blood brain barrier, thus, the current drugs are not able to reach the brain parenchyma (67)

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There are a number of reasons why the brain is more vulnerable to oxidative stress: These factors are all exacerbated by age and clearly play a part in the development of neurodegenerative diseases

The mechanisms involved are beyond the scope of this review, but it is important to note that this post-translational modification offers another route relaying subtle redox-mediated metabolic changes to protein function [110]

PMID: 51 MaSHuis In't VeldRVHaoYGuZRichCGelmiMCet al

These findings suggest that GPX4 inhibition may induce ferroptosis in oligodendrocytes, with Lip-1 serving as a potent ferroptosis antagonist