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This may be one of the main reasons why effective neurological treatments are difficult to develop

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Neuropathological Features of Parkinson's Disease Parkinson's disease is characterized by distinct neuropathological hallmarks, primarily involving intracellular Lewy bodies and dopaminergic neuron degeneration

SKAP2 / PMNs fail to produce superoxide when stimulated with RGD and produce significantly less ROS when stimulated with ICAM-1 and fibrinogen in the presence of TNF (Boras et al., 2010