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While such activity has been recognized for a long time, the protein that exhibits glutathione-specific -glutamylcyclotransferase activity was only recently identified

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Studies show that the concentration may fall from 200 ng/mL at 20 years old to just 80 ng/mL at 60 years of age

In addition, a recent study showed that a high expression of GSTs in lung fibroblasts promotes the progression of pulmonary fibrosis by catalyzing protein S-glutathionylation in lung fibroblast [22]

Biochim Biophys Acta 1205:118