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These free radicals are produced via several pathways, including the activation of the enzyme CYP2E1, which becomes increasingly active as alcohol intake rises

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Oxidative stress and autophagic alteration in brainstem of SOD1-G93A mouse model of ALS

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A recent study on colorectal cancer demonstrated the role of BMP2 in reducing growth, enhancing apoptosis, and decreasing the development of tumors in vivo (Vishnubalaji et al., 2016), supporting that the decreased expression of BMP2 also leads to the progression of prostate cancer (Horvath et al., 2004)