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Dado que los tres agentes tienen mecanismos y cinticas distintos, los diseos suelen contemplar brazos comparativos: cada componente por separado frente al blend completo, para poder atribuir efectos observados a la coformulacin o a sus partes

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(5) Research has shown that by preserving nicotinamide from NNMT-mediated degradation, the compound may enhance NAD+ synthesis through the salvage pathway