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GHK-Cu also stimulates both collagen synthesis and matrix metalloproteinases that break collagen down, so unbalanced or excessive use could in principle disrupt extracellular-matrix homeostasis

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doi:10.3389/fnut.2023.1266056

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The pathophysiology of male infertility and the crucial role of miRNAs in spermatogenesis have been clarified by thorough examinations of miRNA expression profiles in spermatozoa derived from prepubertally hemicastrated Yorkshire, Landrace, and Duroc boars [205, 206]