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NO epigenetic effects are mediated by transcriptional regulation of histone-modifying enzymes and by perturbing their activities and cellular localizations via formation of ironnitrosyl complexes and S-nitrosothiols

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doi: 10.1016/j.nurpra.2022.04.019

Advantageously, such combination therapies utilize lower dosages of the conventional therapeutics, thus avoiding possible toxicity and adverse side effects incurred when those agents are used as monotherapies

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