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47 Taken together, these data suggest the reduced GSH/GSSG antioxidant capacity is insufficient to counter excessive OH production, and that unopposed OH can reach the nucleus to create the oxidative DNA adduct, 8-oxo-dG

Concurrently, bioenergetic and dynamic rescue interventions seek to restore metabolic homeostasis using complex I chaperones, DRP1 inhibitors (for example Mdivi-1), and precision metabolic rescue like NDI1 gene therapy designed to entirely bypass the defective host complex I [95]

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While considerable progress has since been made in understanding the biological implications of oxidative stress in OSA, continuous positive airway pressure (CPAP) therapy remains the only well-established intervention with proven antioxidant effects

TetrahedronLett 42:60836085 Gharbi I, Issaoui M, El Gharbi S, Gazzeh N, Tekeya M, Mechri B, Flamini G, Hammami M (2017) Butylated hydroxytoluene (BHT) emitted by fungi naturally occurring in olives during their pre-processing storage for improving olive oil stability