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In vivo evidence for the role of choline metabolism in RA comes from studies using the K/BxN serum-transfer mouse model of inflammatory arthritis, where treatment with the choline kinase alpha (ChoK) inhibitor MN58b (3 mg/kg) prevented disease onset (68)

J., Badwan, K., Parker, M

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Cells were subjected to the mitochondrial stress test by sequentially adding oligomycin (2 M), FCCP (1 M), and antimycin/rotenone mix (2 M/2 M)

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