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The GSK-3 inhibitors SB 216763, as well as two histamine H 3 receptor agonists, provided benefit in a mouse model of motor hyperactivity or stereotypies resulting from dopamine D 1 agonist exposure, Reference Miller, Tallarida and Unterwald38,Reference Rapanelli, Frick and Horn39 and the antidyskinetic benefit afforded by TDZD8 (GSK-3 inhibitor) administration in a rat model of levodopa-induced dyskinesia was blocked by pretreatment with a selective dopamine D 1 agonist

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Keen CL, Uriu-Hare JY, Hawk SN, Jankowski MA, Daston GP, Kwik-Uribe CL, et al

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[ [PMID: 16322368]

The link between neuronal dysfunction and depression is well-established (55, 56), and numerous researches have explored the association between cholesterol and neuronal deficits (57)
