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While an approimately 200 base pair region upstream of the translational initiation site of the cytosolic isoform (3-ATG) of the murine Gpx4 gene contains binding sites for stimulating protein 1/3, nuclear factor Y and members of the SMAD family [78], regulation of Gpx4 by the oxidative stress sensing Kelch-like ECH-associated protein 1-(KEAP1)/nuclear factor-erythroid 2-related factor 2 (Nrf2) system remains strongly debated and also less likely due to the lack of related structural cis -elements in its promoter region

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On April 22th, 2021, the color doppler ultrasound revealed pancreatic space-occupying, following this, relevant examinations were performed to confirm the diagnose of pancreatic head cancer, gastric wall invasion, and abdominal lymph node metastasis

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