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Comparison of melanocytes staining with melanin content of hair bulbs showed the expected gradual decrease in melanocyte labelling from fully pigmented to weakly/non-pigmented hair bulbs (Fig

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Notably, the intranasal delivery of drugs, including small molecules, nanoformulations and gene delivery agents, has shown promising outcomes in various rodent models of several neurological pathologies

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With regard to distribution , for drugs such as diazepam 1 and penfluridol 5 that are substantially distributed into adipose tissue, greater adiposity is associated with greater storage of the drug in lipid reservoirs, and hence greater availability of the drug for return to blood as blood levels fall due to metabolism

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doi: 10.1038/nrclinonc.2016.60 3 KrebsHAEgglestonLVHemsR

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Health authorities rightly require extensive clinical trials before officially marketing hydrogen water, for example, as a means of reducing inflammation or protecting against disease

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