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Free Radic Biol Med (2015) 84:22745

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[DOI] [PMC free article] [PubMed] [Google Scholar] 178.Goedert M, and Jakes R

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Mechanism of the Michael Reaction The Michael reaction involves just three key steps: deprotonation of the starting material to give an enolate conjugate addition (1,4-addition) of the enolate to an electrophilic alkene, and protonation of the resulting enolate Lets look at the first step with a malonic ester like in the first example of this article