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Treatment starts at 0.25 mg weekly and increases every four weeks through 0.5 mg, 1.0 mg, and 1.7 mg before reaching the maintenance dose of 2.4 mg per week

Indeed, even in this study, overexpression of SHM2 in GCI/ SER33 , GCI/ SER3 / SER33 , and GCI/ SERs didnt improve glutathione production (Fig

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Consequently, the elevated levels of free radicals can damage cellular structures, resulting in the accumulation of cytotoxic substances and ultimately leading to the death of substantia nigra cells, thereby triggering the onset of PD (Chittasupho et al., 2022)

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