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56 Microvesicles from MM patients have also been found to express functional adenosinergic ectoenzymes that can produce ADO from ATP and NAD + , 57 while treatment in vivo with daratumumab can induce the release of microvesicles expressing CD38, among other molecules such as CD39, CD73, CD203a, PDL1, CD55, and CD59

SA--Gal stain SA--Gal staining of cells and tissues was performed using a senescence-associated -galactosidase staining kit (C0602, Beyotime Biotechnology, Shanghai, China), with all procedures strictly following the manufacturers instructions

The standard research titration mirrors what clinical trials established

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FIGURE 7 3.7 Histopathology findings Figure 8A shows the features of MTX-induced hepatopathy detected in the liver sections of MTX rats