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Potapovich AI, Lulli D, Fidanza P, Kostyuk VA, De Luca C, Pastore S, et al

Salehi B et al (2019) Insights on the use of alpha-Lipoic acid for therapeutic purposes

The primary internal sources of cellular redox-reactive species, encompassing ROS and RNS, include various cellular components like the mitochondrial electron transport chain (ETC), endoplasmic reticulum (ER), peroxisomes, membrane-bound NADPH oxidase (NOX) isoforms 15, dual oxidases (Duox) 1 and 2 complexes, and NO synthases isoforms 15 (NOS15)

Generally, 90% of phosphorylated -Syn is deposited in Lewy bodies, and only 4% of -Syn is phosphorylated in normal brain tissue

A phase 1, multiple-dose study of Vedolizumab in Japanese Patients With Ulcerative Colitis